Exchange diagram where the outgoing electrons are swapped relative to the t-channel. Required by Fermi statistics: the total amplitude must be antisymmetric under $p_1' \leftrightarrow p_2'$. Enters with a relative minus sign.
The computational chain
From diagram to number—every step of the amplitude calculation.
Exchange diagram
$$i\mathcal{M}_u = \frac{ie^2}{u}\left[\bar{u}(p_2')\gamma^\mu u(p_1)\right]\left[\bar{u}(p_1')\gamma_\mu u(p_2)\right]$$
Same structure as the t-channel but with the outgoing electrons swapped: $p_1' \leftrightarrow p_2'$. Fermi statistics requires this diagram and it enters the total amplitude with a relative minus sign: $\mathcal{M} = \mathcal{M}_t - \mathcal{M}_u$.